Consumption rate of proteinous diets in place of carbohydrate though increase the rate of glomerular filtration with associated long term kidney disease progression (Stephen et al., 2018.,).Recent studies have shown an increasing trend of high protein intake in diet due to weight loss which may promote renal damage by increasing the glomerular pressure and hyper filtration (Williams et al., 2005). As EEAC has promising results toward hyperglycemia and hyperlipidemia and has been proven safe through toxicity tests, it can be concluded that EEAC has good potential to be further developed into antidiabetic drugs. Also, all animals survived, and no obvious destructive outcomes were noticeable during the study. The results confirmed that EEAC reduced fasting blood glucose levels and stepped forward lipid profiles of rats. When the treatment period ended, hematological, biochemical, and histological examinations of liver, kidneys, and heart sections were performed. General behavior changes, appearance, signs of toxicity, mortality, and body weight of animals were marked down during the observation period. After confirming the antidiabetic properties of EEAC, the toxicological assessment was determined using the fixed-dose method. Determination of antidiabetic properties was done by analyzing lipid profiles as well as fasting blood glucose. Rats were treated with EEAC at 200 and 400 mg/kg BW doses for 28-days and 60 mg/kg BW acarbose for the control group. Male rats (170–280 g) were induced diabetic with streptozotocin (35 mg/kg BW) and fed a high-fat diet comprising 24% fat, whereas control group rats were given a standard diet. celebicum leaves (EEAC) in Sprague–Dawley rats. Therefore, this research managed to verify the antidiabetic features and safety of ethanolic extract of A. However, no scientific studies have reported its antidiabetic properties and toxicity in vivo. Leaves of Kayu Tuah (Antidesma celebicum Miq) have been proven to have the best α-glucosidase inhibition ability compared to other species in the Antidesma genus, as evidenced by the in vitro α-glucosidase inhibition test. While protein restriction may be appropriate for treatment of existing kidney disease, we find no significant evidence for a detrimental effect of high protein intakes on kidney function in healthy persons after centuries of a high protein Western diet.Īntidesma is a genus of plants, and its several species are known to have antidiabetic properties. This paper reviews the available evidence that increased dietary protein intake is a health concern in terms of the potential to initiate or promote renal disease. In fact, some studies suggest that hyperfiltration, the purported mechanism for renal damage, is a normal adaptative mechanism that occurs in response to several physiological conditions. There is, however, a serious question as to whether there is significant evidence to support this relationship in healthy individuals. In particular, there is concern that high protein intake may promote renal damage by chronically increasing glomerular pressure and hyperfiltration.
As a result, the safety of habitually consuming dietary protein in excess of recommended intakes has been questioned. Finalist in the South African Entrepreneur of the Year Awards.Recent trends in weight loss diets have led to a substantial increase in protein intake by individuals.I’ve been honoured to be recognized as the recipient of several awards, including: Partners for Change Holdings: Managing Director.
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